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  • STAP1 抗原（重組蛋白）

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    • 品牌 : 通蔚生物
    • 目錄號(hào) : TW5592
    • 應(yīng)用 : 僅供科研使用
    • 保存條件 : 低溫保存
    • 貨期 : 現(xiàn)貨
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中文名稱： STAP1 抗原（重組蛋白）

英文名稱： STAP1 Antigen (Recombinant Protein)

別      名： signal transducing adaptor family member 1; BRDG1; STAP-1

相關(guān)類別：抗原

儲(chǔ)      存： 冷凍（-20℃）

概     述

Fusion protein corresponding to a region derived from 96-295 amino acids of human STAP1

技術(shù)規(guī)格

Full name:

signal transducing adaptor family member 1

Synonyms:

BRDG1; STAP-1

Swissprot:

Q9ULZ2

Gene Accession:

BC014958

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

The protein encoded by this gene contains a proline-rich region, a pleckstrin homology (PH) domain, and a region in the carboxy terminal half with similarity to the Src Homology 2 (SH2) domain. This protein is a substrate of tyrosine-protein kinase Tec, and its interaction with tyrosine-protein kinase Tec is phosphorylation-dependent. This protein is thought to participate in a positive feedback loop by upregulating the activity of tyrosine-protein kinase Tec. Variants of this gene have been associated with autosomal-dominant hypercholesterolemia (ADH), which is characterized by elevated low-density lipoprotein cholesterol levels and in increased risk of coronary vascular disease. Alternative splicing results in multiple transcript variants.