兔抗CENPA多克隆抗體

Background:

Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. CENPA encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. CENPA is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Applications:

IHC

Name of antibody:

CENPA

Immunogen:

Synthesized peptide derived from internal of human CENPA.

Full name:

centromere protein A

Synonyms：

CenH3; CENP-A

SwissProt:

P49450

IHC positive control:

Human breast carcinoma tissue

IHC Recommend dilution:

50-100