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  • ZNF131 抗原（重組蛋白）

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    • 品牌 : 通蔚生物
    • 目錄號 : TW6742
    • 應(yīng)用 : 僅供科研使用
    • 保存條件 : 低溫保存
    • 貨期 : 現(xiàn)貨
    • 商品庫存：20
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中文名稱： ZNF131 抗原（重組蛋白）

英文名稱： ZNF131 Antigen (Recombinant Protein)

別     名： zinc finger protein 131; ZBTB35; pHZ-10

相關(guān)類別：抗原

儲     存： 冷凍（-20℃）

概     述

Fusion protein corresponding to a region derived from 424-623 amino acids of human ZNF131

技術(shù)規(guī)格

Full name:

zinc finger protein 131

Synonyms:

ZBTB35; pHZ-10

Swissprot:

P52739

Gene Accession:

BC035875

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Krüppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. As a member of the krueppel C2H2-type zinc-finger protein family, ZNF131 (Zinc finger protein 131) is a 623 amino acid nuclear protein that contains one BTB (POZ) domain and six C2H2-type zinc fingers. With predominant expression found in brain, it is likely that ZNF131 plays a role as a transcription regulator during development and organogenesis of the adult central nervous system. ZNF131 also represses ER? (Estrogen receptor alpha)-mediated transactivation by interrupting ER? binding to the estrogen-response element. There are two isoforms of ZNF131 that are produced as a result of alternative splicing events.