小鼠抗EGFR單克隆抗體

Background:

The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer.

Applications:

WB, IHC

Name of antibody:

EGFR

Immunogen:

Fusion protein of human EGFR

Full name:

epidermal growth factor receptor

Synonyms:

ERBB; HER1; mENA; ERBB1; PIG61; NISBD2

SwissProt:

P00533

IHC positive control:

Human tonsil and Human liver cancer; Human esophagus cancer

IHC Recommend dilution:

100-500

WB Predicted band size:

134 kDa

WB Positive control:

SKOV3 and PC3 cell lysates

WB Recommended dilution:

1000-5000