小鼠抗FBXO22單克隆抗體

Background:

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and, as a transcriptional target of the tumor protein p53, is thought to be involved in degradation of specific proteins in response to p53 induction. Alternative splicing results in multiple transcript variants.

Applications:

WB

Name of antibody:

FBXO22

Immunogen:

Fusion protein of human FBXO22

Full name:

F-box protein 22

Synonyms:

FBX22; FISTC1

SwissProt:

Q8NEZ5

WB Predicted band size:

45 KD

WB Positive control:

A549, HepG2 cell, Mouse heart tissue lysates

WB Recommended dilution:

500-2000