小鼠抗MMP2單克隆抗體

Background:

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

Applications:

WB

Name of antibody:

MMP2

Immunogen:

Fusion protein of human MMP2

Full name:

matrix metallopeptidase 2 (MMP2), transcript variant 1

Synonyms:

CLG4; CLG4A; MMP-2; MMP-II; MONA; TBE-1

SwissProt:

P08253

WB Predicted band size:

74 kDa

WB Positive control:

HepG2, SVT2, Jurkat, MCF-7 cell lysates

WB Recommended dilution:

500-2000