兔抗ABCB7多克隆抗體

IHC Recommend dilution:

25-100

IHC positive control:

Human esophagus cancer and human thyroid cancer

ELISA Recommended dilution:

2000-5000

SwissProt:

O75027

Synonyms：

ABC7; ASAT; Atm1p; EST140535

Full name:

ATP-binding cassette, sub-family B (MDR/TAP), member 7

Immunogen:

Fusion protein of human ABCB7

Name of antibody:

ABCB7

Applications:

ELISA, IHC

Background:

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a half-transporter involved in the transport of heme from the mitochondria to the cytosol. With iron/sulfur cluster precursors as its substrates, this protein may play a role in metal homeostasis. Mutations in this gene have been associated with mitochondrial iron accumulation and isodicentric (X)(q13) and sideroblastic anemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.