兔抗IGF1R(Phospho-Tyr1346) 多克隆抗體

Background:

This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Applications:

IHC

Name of antibody:

IGF1R(Phospho-Tyr1346)

Immunogen:

Peptide sequence around phosphorylation site of tyrosine 1346(Q-P-Y(p)-A-H) derived from Human IGF1R .

Full name:

insulin-like growth factor 1 receptor

Synonyms：

IGFR; CD221; IGFIR; JTK13

SwissProt:

P08069

IHC positive control:

Human brain tissue

IHC Recommend dilution:

50-100