購物車
幫助
021-54845833/15800441009
中文名稱：COX10抗原（重組蛋白）
英文名稱：COX10 Antigen (Recombinant Protein)
儲 存：冷凍（-20℃）
相關(guān)類別：抗原
概述
|
Fusion protein corresponding to N terminal 300 amino acids of human COX10 |
技術(shù)規(guī)格
|
Full name: |
COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase |
|
Swissprot: |
Q12887 |
|
Gene Accession: |
BC000060 |
|
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
|
Expression system: |
Escherichia coli |
|
Tags: |
His tag C-Terminus, GST tag N-Terminus |
|
Background: |
Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes heme A:farnesyltransferase, which is not a structural subunit but required for the expression of functional COX and functions in the maturation of the heme A prosthetic group of COX. This protein is predicted to contain 7-9 transmembrane domains localized in the mitochondrial inner membrane. A gene mutation, which results in the substitution of a lysine for an asparagine (N204K), is identified to be responsible for cytochrome c oxidase deficiency. In addition, this gene is disrupted in patients with CMT1A (Charcot-Marie-Tooth type 1A) duplication and with HNPP (hereditary neuropathy with liability to pressure palsies) deletion. |
