小鼠抗PPP2R1B單克隆抗體

Background:

This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes a beta isoform of the constant regulatory subunit A. Mutations in this gene have been associated with some lung and colon cancers. Alternatively spliced transcript variants have been described.

Applications:

WB

Name of antibody:

PPP2R1B

Immunogen:

Fusion protein of human PPP2R1B

Full name:

protein phosphatase 2 scaffold subunit Abeta

Synonyms:

PR65B; PP2A-Abeta

SwissProt:

P30154

WB Predicted band size:

66 KD

WB Positive control:

Jurkat, HEK293, Hela cell lysates

WB Recommended dilution:

500-2000