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  • BCL6B抗原（重組蛋白）

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    • 品牌 : 通蔚生物
    • 目錄號 : TW16284
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中文名稱： BCL6B抗原（重組蛋白）
英文名稱： BCL6B Antigen (Recombinant Protein)
別       名： B-cell CLL/lymphoma 6B; BAZF; ZNF62; ZBTB28
相關(guān)類別： 抗原

儲       存： 冷凍（-20℃）
概述

Fusion protein corresponding to a region derived from 280-479 amino acids of human BCL6B

技術(shù)規(guī)格

Full name:

B-cell CLL/lymphoma 6B

Synonyms:

BAZF; ZNF62; ZBTB28

Swissprot:

Q8N143

Gene Accession:

BC059404

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

Bcl-6, a transcriptional repressor, binds Stat recognition-like DNA elements and influences germinal center development and cell differentiation. Additionally, Bcl-6 negatively regulates NF?B expression, thereby inhibiting NF?B-mediated cellular functions. Bcl-6b (B-cell CLL/lymphoma 6, member B), also known as ZNF62, BAZF or ZBTB28, is a 480 amino acid nuclear protein that contains one BTB (POZ) domain and five C2H2-type zinc fingers. Expressed ubiquitously with highest expression in placenta and heart, Bcl-6b associates with Bcl-6 and functions as a sequence-specific transcriptional repressor that is thought to be necessary for early B-cell development. The gene encoding Bcl-6b maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes.