歡迎來到上海通蔚！

021-54845833/15800441009

品質(zhì)保證 · 通蔚試劑

當前位置: 首頁 > 科研產(chǎn)品 > 科研抗體 > 其他抗體 > ORC1抗原（重組蛋白）

產(chǎn)品中心

  • ORC1抗原（重組蛋白）

    規(guī)格：
    數(shù)量：

    購買數(shù)量

    價格：￥
    • 品牌 : 通蔚生物
    • 目錄號 : TW17912
    • 應(yīng)用 : 僅供科研使用
    • 保存條件 : 低溫保存
    • 貨期 : 現(xiàn)貨
    • 商品庫存：40
  • 商品詳情
  • 參考文獻
  • 說明書下載
  • 商品評論0
  • 相關(guān)產(chǎn)品
中文名稱：ORC1抗原（重組蛋白）

英文名稱： ORC1 Antigen (Recombinant Protein)
別       名： origin recognition complex subunit 1; ORC1L; PARC1; HSORC1
儲       存： 冷凍（-20℃）
相關(guān)類別： 抗原

概述

Fusion protein corresponding to a region derived from 662-861 amino acids of human ORC1

技術(shù)規(guī)格

Full name:

origin recognition complex subunit 1

Synonyms:

ORC1L; PARC1; HSORC1

Swissprot:

Q13415

Gene Accession:

BC011539

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is the largest subunit of the ORC complex. While other ORC subunits are stable throughout the cell cycle, the levels of this protein vary during the cell cycle, which has been shown to be controlled by ubiquitin-mediated proteolysis after initiation of DNA replication. This protein is found to be selectively phosphorylated during mitosis. It is also reported to interact with MYST histone acetyltransferase 2 (MyST2/HBO1), a protein involved in control of transcription silencing. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.