兔抗DEAF1多克隆抗體

Background:

Suppressin, also known as DEAF1 (deformed epidermal autoregulatory factor 1), SPN, NUDR (nuclear DEAF-1-related transcriptional regulator), or ZMYND5 (zinc finger MYND domain-containing protein 5), is a transcription factor required for embryonic development. Suppressin contains one SAND domain and one C-terminal MYND-type zinc finger. It interacts with LMO4 and CLIM-2, suggesting that it plays a role mediating cell fate and embryonic pattern formation. Suppressin is expressed in a variety of tissues and localizes to the nucleus. Several isoforms exist due to alternative splicing and, depending on the isoform, Suppressin is secreted in some cell types. Secreted Suppressin can function to inhibit cell proliferation, arresting cells in the G0 or G1 phase. Mutations in the gene encoding Suppressin may result in a growth advantage leading to the development and progression of neoplasia. This suggest that Supressin is a potential target for cancer therapy.

Applications:

ELISA, IHC

Name of antibody:

DEAF1

Immunogen:

Synthetic peptide of human DEAF1

Full name:

DEAF1 transcription factor

Synonyms:

SPN; NUDR; ZMYND5

SwissProt:

O75398

IHC positive control:

Human gastric cancer

IHC Recommend dilution:

50-200