購(gòu)物車
幫助
021-54845833/15800441009
中文名稱： 兔抗NUAK1多克隆抗體
英文名稱： Anti-NUAK1 rabbit polyclonal antibody
別 名： ARK5
相關(guān)類別： 一抗
儲(chǔ) 存： 冷凍（-20℃）
宿 主： Rabbit
抗 原： NUAK1
反應(yīng)種屬： Human, Mouse
標(biāo) 記 物： Unconjugate
克隆類型： rabbit polyclonal
技術(shù)規(guī)格
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Background: |
NUAK family SNF1-like kinase 1 also known as AMPK-related protein kinase 5 (ARK5) is an enzyme that in humans is encoded by the NUAK1 gene. Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1: phosphorylated PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1. |
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Applications: |
ELISA, IHC |
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Name of antibody: |
NUAK1 |
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Immunogen: |
Synthetic peptide of human NUAK1 |
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Full name: |
NUAK family, SNF1-like kinase, 1 |
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Synonyms： |
ARK5 |
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SwissProt: |
O60285 |
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ELISA Recommended dilution: |
2000-10000 |
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IHC positive control: |
Human lung cancer and Human liver cancer |
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IHC Recommend dilution: |
100-300 |
