購物車
幫助
021-54845833/15800441009
中文名稱： 兔抗PSEN1多克隆抗體
英文名稱： Anti-PSEN1 rabbit polyclonal antibody
別 名： presenilin 1 AD3; FAD; PS1; PS-1; S182
相關(guān)類別： 一抗
抗 原： PSEN1
儲(chǔ) 存： 冷凍（-20℃）
宿 主： Rabbit
反應(yīng)種屬： Human, Mouse
標(biāo) 記 物： Unconjugate
克隆類型： rabbit polyclonal
|
Background: |
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. |
|
Applications: |
ELISA, WB, IHC |
|
Name of antibody: |
PSEN1 |
|
Immunogen: |
Synthetic peptide of human PSEN1 |
|
Full name: |
presenilin 1 |
|
Synonyms: |
AD3; FAD; PS1; PS-1; S182 |
|
SwissProt: |
P49768 |
|
ELISA Recommended dilution: |
5000-10000 |
|
IHC positive control: |
Human liver cancer; |
|
IHC Recommend dilution: |
20-100 |
|
WB Predicted band size: |
53 kDa |
|
WB Positive control: |
Human kidney tissue，RAW264.7 cell，Mouse kidney tissue，Mouse liver tissue lysates |
|
WB Recommended dilution: |
200-1000 |
