兔抗CDH5多克隆抗體

Background:

This gene is a classical cadherin from the cadherin superfamily and is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classic cadherin by imparting to cells the ability to adhere in a homophilic manner, the protein may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. An alternative splice variant has been described but its full length sequence has not been determined.

Applications:

ELISA, IHC

Name of antibody:

CDH5

Immunogen:

Synthetic peptide of human CDH5

Full name:

cadherin 5, type 2 (vascular endothelium)

Synonyms：

7B4; CD144

SwissProt:

P33151

ELISA Recommended dilution:

2000-20000

IHC positive control:

Human thyroid cancer and human ovarian cancer

IHC Recommend dilution:

50-200