兔抗CDH8多克隆抗體

Background:

This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is expressed in brain and is putatively involved in synaptic adhesion, axon outgrowth and guidance.

Applications:

WB, IHC, IF

Name of antibody:

CDH8

Immunogen:

Synthesized peptide derived from internal of human CDH8.

Full name:

cadherin 8, type 2

Synonyms：

Nbla04261

SwissProt:

P55286

IHC positive control:

Human brain tissue

IHC Recommend dilution:

50-100

WB Predicted band size:

88 kDa

WB Positive control:

RAW264.7 cells lysate

WB Recommended dilution:

500-3000

IF positive control:

COS7 cells

IF Recommend dilution:

100-500