購(gòu)物車
幫助
021-54845833/15800441009
中文名稱：兔抗CDK3多克隆抗體
英文名稱： Anti-CDK3 rabbit polyclonal antibody
相關(guān)類別： 一抗
儲(chǔ) 存： 冷凍（-20℃）
抗 原： CDK3
宿 主： Rabbit
反應(yīng)種屬： Human, Mouse
標(biāo) 記 物： Unconjugate
克隆類型： rabbit polyclonal
技術(shù)規(guī)格
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Background: |
This gene encodes a member of the cyclin-dependent protein kinase family. The protein promotes entry into S phase, in part by activating members of the E2F family of transcription factors. The protein also associates with cyclin C and phosphorylates the retinoblastoma 1 protein to promote exit from G0. Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle; involved in G0-G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2 and E2F3 in a RB1-independent manner. |
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Applications: |
ELISA, IHC |
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Name of antibody: |
CDK3 |
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Immunogen: |
Synthetic peptide of human CDK3 |
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Full name: |
cyclin-dependent kinase 3 |
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SwissProt: |
Q00526 |
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ELISA Recommended dilution: |
1000-5000 |
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IHC positive control: |
Human lung cancer |
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IHC Recommend dilution: |
25-100 |
