兔抗CDK14多克隆抗體

Background:

Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport.

Applications:

ELISA, WB, IHC

Name of antibody:

CDK14

Immunogen:

Synthetic peptide of human CDK14

Full name:

cyclin-dependent kinase 14

Synonyms:

PFTK1; PFTAIRE1

SwissProt:

O94921

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human liver cancer

IHC Recommend dilution:

20-100

WB Predicted band size:

53 kDa

WB Positive control:

Mouse Pancreas tissue lysate

WB Recommended dilution:

200-1000