購(gòu)物車
幫助
021-54845833/15800441009
中文名稱：小鼠抗CRTC1單克隆抗體
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Background: |
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons (By similarity). In concert with SIK1, regulates the light-induced entrainment of the circadian clock. In response to light stimulus, coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock. |
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Applications: |
WB, FC, IF, IP |
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Name of antibody: |
CRTC1 |
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Immunogen: |
Fusion protein of human CRTC1 |
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Full name: |
CREB regulated transcription coactivator 1 |
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Synonyms: |
MECT1; TORC1; TORC-1; WAMTP1 |
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SwissProt: |
Q6UUV9 |
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WB Predicted band size: |
67 kDa |
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WB Positive control: |
Hela and Jurkat cell lysates |
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WB Recommended dilution: |
1000-5000 |
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IF positive control: |
Hela cells |
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IF Recommend dilution: |
150-300 |
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FC Recommend dilution: |
50-100 |
