小鼠抗HOXD8單克隆抗體

Background:

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. In addition to effects during embryogenesis, this particular gene may also play a role in adult urogenital tract function. Alternate splicing results in multiple transcript variants.

Applications:

WB

Name of antibody:

HOXD8

Immunogen:

Fusion protein of human HOXD8

Full name:

homeobox D8

Synonyms:

HOX4; HOX4E; HOX5.4

SwissProt:

P13378

WB Predicted band size:

32 KD

WB Positive control:

293T, A375, A431 cell lysates

WB Recommended dilution:

500-2000