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021-54845833/15800441009
中文名稱：CASP10抗原（重組蛋白）
英文名稱：CASP10 Antigen (Recombinant Protein)
儲 存：冷凍（-20℃）
相關(guān)類別：抗原
概述
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Fusion protein corresponding to a region derived from 228-522 amino acids of human CASP10 |
技術(shù)規(guī)格
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Full name: |
caspase 10, apoptosis-related cysteine peptidase |
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Synonyms: |
MCH4; ALPS2; FLICE2 |
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Swissprot: |
Q92851 |
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Gene Accession: |
BC042844 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. |
