兔抗PGRMC2多克隆抗體

Background:

PGRMC2 (progesterone receptor membrane component 2), also known as DG6 (steroid receptor protein DG6) or PMBP (progesterone membrane-binding protein), is a single pass membrane protein belonging to the cytochrome b5 family (MAPR (membrane associated progesterone receptor) subfamily). Expressed in sperm, PGRMC2 is believed to function as a steroid receptor and may participate in the progesterone-dependent sperm acrosome reaction. PGRMC2 shares approximately 50% overall sequence identity with its close relative PGRMC1. The loss of the gene encoding PGRMC2 is associated with metastasis in uterine endocervical adenocarcinomas, implicating a potential role of PGRMC2 in the suppression of metastasis of endocervical adenocarcinomas.

Applications:

ELISA, WB, IHC

Name of antibody:

PGRMC2

Immunogen:

Fusion protein of human PGRMC2

Full name:

progesterone receptor membrane component 2

Synonyms:

DG6; PMBP

SwissProt:

O15173

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human thyroid cancer and Human tonsil

IHC Recommend dilution:

50-200

WB Predicted band size:

24 kDa

WB Positive control:

RAW264.7 and NIH/3T3 cell lysates

WB Recommended dilution:

500-2000