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中文名稱： 兔抗PRKAA1/PRKAA2(Phospho-Thr183/Thr172)多克隆抗體
英文名稱： Anti-PRKAA1/PRKAA2(Phospho-Thr183/Thr172) rabbit polyclonal antibody
別 名： AMPK; AMPKa1
相關(guān)類別： 一抗
儲 存： 冷凍（-20℃） 避光
宿 主： Rabbit
抗 原： PRKAA1/PRKAA2(Phospho-Thr183/Thr172)
反應(yīng)種屬： Human, Mouse, Rat
標(biāo) 記 物： Unconjugate
克隆類型： rabbit polyclonal
技術(shù)規(guī)格
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Background: |
The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. |
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Applications: |
WB, IHC |
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Name of antibody: |
PRKAA1/PRKAA2(Phospho-Thr183/Thr172) |
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Immunogen: |
Peptide sequence around phosphorylation site of threonine 183/threonine172(L-R-T(p)-S-C) derived from Human AMPKα1/AMPKα2. |
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Full name: |
protein kinase AMP-activated catalytic subunit alpha 1/ protein kinase AMP-activated catalytic subunit alpha 2 |
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Synonyms: |
AMPK; AMPKa1; AMPK2; PRKAA; AMPKa2 |
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SwissProt: |
Q13131/P54646 |
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IHC positive control: |
Human lung carcinoma tissue |
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IHC Recommend dilution: |
50-100 |
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WB Predicted band size: |
64 kDa |
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WB Positive control: |
C2C12 cells lysates treated with serum or calf intestinal phosphatase(CIP) |
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WB Recommended dilution: |
500-1000 |
